Innovations in ultra low-light CMOS bio-optical sensor design, combined with microfluidics technology can enable a new generation of low cost, portable molecular diagnostics platforms. This combination of technologies have been applied successfully in a miniaturized qPCR system, and a chemiluminescence microfluidic immunoassay platform to detect a variety of infectious pathogens. Cost reduction and miniaturization of molecular test enabled by this technology will have positive impact on global battle against infectious diseases.