Structural, magnetic and transport property of Pb substituted LaMnO3 (La1−xPbXMnO3; x=0.1, 0.2, 0.3, 0.4, 0.5) prepared by solid state reaction route have been studied systematically. X-ray diffraction,SEM, VSM,magneto-transport measurements were carried out on prepared samples. All the samples below x=0.4 composition were crystallized into single phase with R-3C space group of trigonal crystal class. The explored physical properties like magnetoresistance (MR), resistivity, metal–insulator transition temperature (TP), magnetization (Ms)and Curie temp. (TC) varies with Pb concentration. Higher TP (298 K) and minimum resistivity was recorded for x=0.3 sample whereas no distinct peak corresponding to metal-insulator transition was observed for La0.5Pb0.5MnO3. Appreciable magnetoresistance (MR%) values were obtained for all the samples at 300 K.X-ray photoelectron spectroscopy (XPS) confirms the +2 oxidation state of Pb in all substituted samples. Fine tuning of Tc could be achieved by varying Pb concentration in substituted LaMnO3samples, hence, it can find application in the field of cancer treatment i.e. Magnetic Hyperthermia.