ترکیب کریستالیزاسیون با تعیین مدل پارامترهای مدل تجربی و مدل سازی به طراحی فرایند مفهومی برای تمیز کردن ترکیبات خوراکی پیچیده

A one-dimensional population balance model is combined with experiments, which are selected and carried out as a typical example for an industrial fermentation broth (e.g. vanillin), focusing on determination of solubility and growth kinetics as well as kinetics of agglomeration and breakage. Model parameter determination and model validation show that the named effects are adequately described by the model. Hence, model-based process design of purification by crystallization and particle formation enabling integration into formulation considering relevant effects regarding a complex feed mixture becomes possible within a conceptual process design. Further applications are under consideration.