دانلود مقاله ISI انگلیسی شماره 75233
عنوان فارسی مقاله

مواد مخدر وابسته به استرس و مدولاسیون آدرنرژیک حافظه ترس تازه بازیابی شده

کد مقاله سال انتشار مقاله انگلیسی ترجمه فارسی تعداد کلمات
75233 2014 6 صفحه PDF سفارش دهید محاسبه نشده
خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.
عنوان انگلیسی
Stress-dependent opioid and adrenergic modulation of newly retrieved fear memory
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 109, March 2014, Pages 1–6

کلمات کلیدی
حداقل تفاوت معنادار؛ وسیله نقلیه؛ نهایی، نالوکسان؛ نرم افزار، پروپرانولول؛فشار؛ مواد مخدر؛ آدرنرژیک؛ بازیابی
پیش نمایش مقاله
پیش نمایش مقاله مواد مخدر وابسته به استرس و مدولاسیون آدرنرژیک حافظه ترس تازه بازیابی شده

چکیده انگلیسی

Recent studies on the effect of stress on modulation of fear memory in our laboratory have uncovered endogenous opioid and adrenergic based modulation systems, working in concert, that limit the strengthening or weakening of newly acquired fear memory during consolidation under conditions of mild or intense stress, respectively. The present study sought to determine if similar stress-dependent modulation, mediated by endogenous opioid and adrenergic systems, occurs during reconsolidation of newly retrieved fear memory. Rats underwent contextual fear conditioning followed 24 h later by reactivation of fear memory; a retention test was administered the next day. Stress was manipulated by varying duration of recall of fear memory during reactivation. In the first experiment, vehicle or the opioid-receptor blocker naloxone was administered immediately after varied durations (30 or 120 s) of reactivation. The results indicate that (1) reactivation, in the absence of drug, has a marked effect on freezing behavior—as duration of reactivation increases from 30 to 120 s, freezing behavior and presumably fear-induced stress increases and (2) naloxone, administered immediately after 30 s (mild stress) or 120 s (intense stress) of reactivation, enhances or impairs retention, respectively, the next day. In the second experiment, naloxone and the ß-adrenergic blocker propranolol were administered either separately or in combination immediately after 120 s (intense stress) reactivation. The results indicate that separate administration of propranolol and naloxone impairs retention, while the combined administration fails to do so. Taken together the results of the two experiments are consistent with a protective mechanism, mediated by endogenous opioid and adrenergic systems working in concert, that limits enhancement and impairment of newly retrieved fear memory during reactivation in a stress-dependent manner.

خرید مقاله
پس از پرداخت، فوراً می توانید مقاله را دانلود فرمایید.