دانلود مقاله ISI انگلیسی شماره 112676
ترجمه فارسی عنوان مقاله

مقررات تالامیک سقز در معرض بی نظمی پاداش است

عنوان انگلیسی
Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
112676 2017 18 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuron, Volume 94, Issue 2, 19 April 2017, Pages 388-400.e4

پیش نمایش مقاله
پیش نمایش مقاله  مقررات تالامیک سقز در معرض بی نظمی پاداش است

چکیده انگلیسی

The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity under two emotionally distinct conditions: (1) when reward was available during the cue as expected or (2) when reward was unexpectedly omitted during the cue. Pharmacological inactivation of the anterior PVT (aPVT), but not the posterior PVT, increased sucrose seeking only when reward was omitted. Consistent with this, photoactivation of aPVT neurons abolished sucrose seeking, and the firing of aPVT neurons differentiated reward availability. Photoinhibition of aPVT projections to the nucleus accumbens or to the amygdala increased or decreased, respectively, sucrose seeking only when reward was omitted. Our findings suggest that PVT bidirectionally modulates sucrose seeking under the negative (frustrative) conditions of reward omission.