دانلود مقاله ISI انگلیسی شماره 120605
ترجمه فارسی عنوان مقاله

محروم شدن از اوایل، در آزمایش میدان باز در موش صحرایی، رفتارهای پرخاشگرانه و رفتارهای اضطرابی جدید را افزایش می دهد

عنوان انگلیسی
Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
120605 2017 30 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuroscience Research, Volume 123, October 2017, Pages 27-35

ترجمه کلمات کلیدی
آزمایش میدان باز، رفتار اضطراب مانند، جدایی مادران، محرومیت اولیه، شدت نور دیازپام،
کلمات کلیدی انگلیسی
Open field test; Anxiety-like behavior; Maternal separation; Early deprivation; Illumination intensity; Diazepam;
پیش نمایش مقاله
پیش نمایش مقاله  محروم شدن از اوایل، در آزمایش میدان باز در موش صحرایی، رفتارهای پرخاشگرانه و رفتارهای اضطرابی جدید را افزایش می دهد

چکیده انگلیسی

The open field test is one of the most popular ethological tests to assess anxiety-like behavior in rodents. In the present study, we examined the effect of early deprivation (ED), a model of early life stress, on anxiety-like behavior in rats. In ED animals, we failed to find significant changes in the time spent in the center or thigmotaxis area of the open field, the common indexes of anxiety-like behavior. However, we found a significant increase in high-leaning behavior in which animals lean against the wall standing on their hindlimbs while touching the wall with their forepaws at a high position. The high-leaning behavior was decreased by treatment with an anxiolytic, diazepam, and it was increased under intense illumination as observed in the center activity. In addition, we compared the high-leaning behavior and center activity under various illumination intensities and found that the high-leaning behavior is more sensitive to illumination intensity than the center activity in the particular illumination range. These results suggest that the high-leaning behavior is a novel anxiety-like behavior in the open field test that can complement the center activity to assess the anxiety state of rats.