Hippocampal subfield volumes at 7T in early Alzheimer's disease and normal aging
آشنایی با موضوع
بیماری آلزایمر شایع ترین نوع دمانس (خردسودگی)، با شروعی تدریجی و پیشرفتی مداوم است که به تدریج حافظه و تواناییهای ذهنی دیگر مانند تفکر، استدلال و قضاوت فرد را تحت تأثیر قرار می دهد و او در انجام وظایف روزانه زندگی با مشکل مواجه می شود. اختلال حافظه معمولاً بتدریج ایجاد شده و پیشرفت می‌کند. در ابتدا اختلال حافظه به وقایع و آموخته‌های اخیر محدود می‌شود ولی بتدریج خاطرات قدیمی هم آسیب می‌بینند. بیمار پاسخ سئوالی را که چند لحظه قبل پرسیده‌است فراموش می‌کند و مجدداً همان سؤال را می‌پرسد. بیمار وسایلش را گم می‌کند و نمی‌داند کجا گذاشته‌است. در خرید و پرداخت پول دچار مشکل می‌شود و نمی‌تواند حساب دارائیش را نگه دارد. بتدریج در شناخت دوستان و آشنایان و نام بردن اسامی آنها نیز مشکل ایجاد می‌شود. کم‌کم مشکل مسیر یابی پیدا شده و اگر تنها از منزل بیرون برود ممکن است گم شود. در موارد شدیدتر حتی در تشخیص اتاق خواب، آشپزخانه، دستشویی و حمام در منزل خودش هم مشکل پیدا می‌کند. بروز اختلال در حافظه و روند تفکر سبب آسیب عملکردهای اجتماعی و شخصی بیمار شده و در نتیجه ممکن است سبب افسردگی، عصبانیت و پرخاشگری بیمار شود. یکی از مشکلات زوال عقل بروز توهم و هذیان است. مثلاً بیمار فکر کند همسرش به وی خیانت کرده‌است و یا همسایگان و پرستارش قصد آسیب رساندن و توطئه علیه وی را دارند. بیمار ممکن است به فرزندانش بدبین شود. گاهی اوقات بیمار افرادی را که نیستند می‌بیند مثلاً والدین فوت شده یا اقوام دیگر.
در این صفحه، تعداد 151 مقاله انگلیسی از ژورنال ها و مجلات معتبر پایگاه ساینس دایرکت (ScienceDirect) درباره موضوع آلزایمر آرشیو شده است که شما می توانید مقالات مورد نظر خود را بر اساس سال انتشار، موضوع مقاله، وضعیت ترجمه و تعداد صفحات، انتخاب نموده و دانلود فرمایید.
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در صورتی که مقاله لاتین مورد نظر شما تا کنون به زبان فارسی ترجمه نشده باشد، واحد ترجمه پایگاه ISI Articles با همکاری تنی چند از اساتید و مترجمان با سابقه، آمادگی دارد آن را در اسرع وقت و با کیفیت مطلوب برای شما ترجمه نماید.
Psychotic Alzheimer's disease is associated with gender-specific tau phosphorylation abnormalities
Different multivariate techniques for automated classification of MRI data in Alzheimer’s disease and mild cognitive impairment
Assessing the impact and social perception of self-regulated music stimulation with patients with Alzheimer's disease
Personality features and cognitive level in patients at an early stage of Alzheimer’s disease
Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative
A longitudinal study of semantic memory impairment in patients with Alzheimer’s disease
Factors in action-object semantic disorder for Chinese-speaking persons with or without Alzheimer's disease
Distinct neuroanatomical bases of episodic and semantic memory performance in Alzheimer’s disease
Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease
Personality and resilience to Alzheimer’s disease neuropathology: a prospective autopsy study
Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer’s disease in mice
Expression level of vascular endothelial growth factor in hippocampus is associated with cognitive impairment in patients with Alzheimer's disease
Decreased mean platelet volume and platelet distribution width are associated with mild cognitive impairment and Alzheimer's disease
Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors
Cognitive assistance to support social integration in Alzheimer's disease
Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study
Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease
Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function
Risk and resilience: A new perspective on Alzheimer's disease
Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome
Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
Alzheimer's disease is associated with distinctive semantic feature loss
Changes in subcortical structures in early- versus late-onset Alzheimer's disease
A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease
Is encroachment of the carotid termination into the substantia innominata associated with its atrophy and cognition in Alzheimer's disease?
Genetic variation in Clusterin gene and Alzheimer's disease risk in Han Chinese
Anosognosia, autobiographical memory and self knowledge in Alzheimer's disease
Localized hippocampus measures are associated with Alzheimer pathology and cognition independent of total hippocampal volume
White matter hyperintensities predict amyloid increase in Alzheimer's disease
Early Alzheimer's disease blocks responses to accelerating self-movement
Bilingualism as a contributor to cognitive reserve: Evidence from brain atrophy in Alzheimer’s disease
ADAM10 expression and promoter haplotype in Alzheimer's disease
Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer's transgenic mice
Modeling regional vulnerability to Alzheimer pathology
Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years
Hypermetabolism in a triple-transgenic mouse model of Alzheimer's disease
Functional correlates of instrumental activities of daily living in mild Alzheimer's disease
Gender differences in apolipoprotein D expression during aging and in Alzheimer disease
Reactive astrocytes give neurons less support: implications for Alzheimer's disease
Alzheimer's pathology in primary progressive aphasia
Traumatic brain injury: A risk factor for Alzheimer's disease
Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's disease
Abnormal temporal dynamics of visual attention in Alzheimer's disease and in dementia with Lewy bodies
Impact of chronic Helicobacter pylori infection on Alzheimer's disease: preliminary results
Diagnosis and assessment of apathy in Chinese patients with Alzheimer's disease
Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression
Emotional reactivity and awareness of task performance in Alzheimer's disease
CSF tau markers are correlated with hippocampal volume in Alzheimer's disease
Analysis of the hexanucleotide repeat in C9ORF72 in Alzheimer's disease
Vitamin D receptor and Alzheimer's disease: a genetic and functional study
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation
Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers
Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease
Impaired acquisition of a mirror-reading skill in Alzheimer's disease
Carvedilol as a potential novel agent for the treatment of Alzheimer's disease
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment
Language-specific effects in Alzheimer’s disease: Subject omission in Italian and English
Altered brain response for semantic knowledge in Alzheimer's disease
No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease
P.1.006 No association between promoter polymorphism of the MAOA gene and Alzheimer's disease
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
False item recognition in patients with Alzheimer's disease
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
Genetic variation in APOE cluster region and Alzheimer's disease risk
Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies
The potential of functional MRI as a biomarker in early Alzheimer's disease
Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study
Repetitive questioning behavior in Alzheimer's disease: Relationship to regional cerebral blood flow
Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation