Cross cultural mentoring for underrepresented minority in medicine (URMM) students has increased significance. It is especially important for non-URMM faculty and others from different backgrounds, ethnicities and cultures to know how to provide mentorship for URMM student success. This article provides approaches to mentorship for URMM students. Recommendations include mentoring around scholarly projects, identifying mentorship role, acknowledging personal attributes for mentoring, addressing racism, stereotypes and bias, collaborating with Historically Black Colleges and Universities and being attentive to the unique needs of URMM students.