دانلود مقاله ISI انگلیسی شماره 157284
ترجمه فارسی عنوان مقاله

تاثیر کاهش وزن با بالون داخل وریدی در تراکم استخوانی و میکروارگانیسم در بزرگسالان چاق

عنوان انگلیسی
Impact of Weight Loss With Intragastric Balloon on Bone Density and Microstructure in Obese Adults
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
157284 2018 26 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Clinical Densitometry, Available online 21 March 2018

ترجمه کلمات کلیدی
ریز ساختار استخوان، تراکم معدنی استخوان، توموگرافی کامپیوتری با وضوح محیطی با وضوح بالا، بالون داخل عضلانی کاهش وزن،
کلمات کلیدی انگلیسی
Bone microstructure; bone mineral density; high-resolution peripheral quantitative computed tomography; intragastric balloon; weight loss;
پیش نمایش مقاله
پیش نمایش مقاله  تاثیر کاهش وزن با بالون داخل وریدی در تراکم استخوانی و میکروارگانیسم در بزرگسالان چاق

چکیده انگلیسی

The historical concept that obesity protects against bone fractures has been questioned. Weight loss appears to reduce bone mineral density (BMD); however, the results in young adults are inconsistent, and data on the effects of weight loss on bone microstructure are limited. This study aimed to evaluate the impact of weight loss using an intragastric balloon (IGB) on bone density and microstructure. Forty obese patients with metabolic syndrome (mean age 35.1 ± 7.3 yr) used an IGB continuously for 6 mo. Laboratory tests, areal BMD, and body composition measurements via dual-energy X-ray absorptiometry, and volumetric BMD and bone microstructure measurements via high-resolution peripheral quantitative computed tomography were conducted before IGB placement and after IGB removal. The mean weight loss was 11.5%. After 6 mo, there were significant increases in vitamin D and carboxyterminal telopeptide of type 1 collagen levels. After IGB use, areal BMD increased in the spine but decreased in the total femur and the 33% radius. Cortical BMD increased in the distal radius but tended to decrease in the distal tibia. The observed trabecular bone loss in the distal tibia contributed to the decline in the total volumetric BMD at this site. There was a negative correlation between the changes in leptin levels and the measures of trabecular quality in the tibia on high-resolution peripheral quantitative computed tomography. Weight loss may negatively impact bone microstructure in young patients, especially for weight-bearing bones, in which obesity has a more prominent effect.