اپیستازی مدل سازی در بیماری های ژنتیکی با استفاده از شبکه های پتری، محاسبات تکاملی و استخراج معادن اقلام مکرر

We demonstrate our method using an epistatic model related to the presence of digital ulcers in systemic sclerosis patients that was recently reported in the literature. Our results show that although individual “perfect” Petri nets can frequently be discovered for this interaction, the true value of this approach lies in generating many different perfect nets, and applying data mining techniques to them in order to elucidate common and statistically significant patterns of interaction.