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In the last five decades, maturity models have been introduced as guides and reference frameworks for information system (IS) management in organizations within different industries and sectors. In the healthcare domain, maturity models have also been used to address a wide variety of challenges, complexities and the high demand for hospital IS (HIS) implementations. The present paper describes a research project focused on the development of a comprehensive maturity model applied in the HIS context. The outcome of this research is the HIS maturity model (hereafter referred to as HISMM), which includes six stages of HIS growth and maturity progression. The HISMM has the peculiarity of congregating a set of key maturity-influencing factors and respective characteristics, enabling not only the assessment of the global maturity of a HIS, but also the individual maturity of its different dimensions.