خوشه های مولکول پلی اکسوماتاالت رادیواکتیو: ارزیابی اختلال عملکرد کلیه و تشخیص تومور با تصویربرداری توموگرافی منتشر شده توسط مثبت

Herein, renal clearable polyoxometalate clusters (POM) were readily radiolabeled with the oxophilic 89Zr to allow for efficient staging of kidney dysfunction in a murine model. Furthermore, the as-synthesized clusters can accumulate in the tumor through enhanced permeability and retention (EPR) effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect. (290KB)