دانلود مقاله ISI انگلیسی شماره 52519
ترجمه فارسی عنوان مقاله

سیتوتوکسیسیته نانوذرات کیتوزان / استرپتوکیناز به عنوان تابع اندازه: مطالعه شبکه عصبی مصنوعی

عنوان انگلیسی
Cytotoxicity of chitosan/streptokinase nanoparticles as a function of size: An artificial neural networks study
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
52519 2016 10 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Nanomedicine: Nanotechnology, Biology and Medicine, Volume 12, Issue 1, January 2016, Pages 171–180

ترجمه کلمات کلیدی
استرپتوکیناز، کیتوزان، شبکه های عصبی مصنوعی، اندازه، سمی بودن
کلمات کلیدی انگلیسی
Streptokinase; Chitosan; Artificial neural networks; Size; Toxicity

چکیده انگلیسی

Predicting the size and toxicity of chitosan/streptokinase nanoparticles at various values of processing parameters was the aim of this study. For the first time, a comprehensive model could be developed to determine the cytotoxicity of the nanoparticles as a function of their size. Then, artificial neural networks were used for identifying main factors influencing self-assembly prepared nanoparticles size and cytotoxicity. Three variables included polymer concentration; pH and stirring time were used for a modeling study. A second modeling was performed to evaluate the influence of particles' size on toxicity. Experimentally data modeled using ANNs was validated against unseen data. The response surfaces generated from the software demonstrated that chitosan concentration is the dominant factor with a direct effect on size. Results also showed that the most important factor in determining the particles' toxicity is size—smaller particles showed more toxic effects, regardless of the effect of other input parameters.