دانلود مقاله ISI انگلیسی شماره 67740
ترجمه فارسی عنوان مقاله

بررسی آزمایشی اکتیگرافی به عنوان یک اقدام هدف از علائم فعال سازی SSRI: نمایش نتایج: از مطالعه درمان روان دارو شناسی پلاسبو با کنترل تصادفی

عنوان انگلیسی
A pilot study of actigraphy as an objective measure of SSRI activation symptoms: Results from a randomized placebo controlled psychopharmacological treatment study
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
67740 2015 6 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 225, Issue 3, 28 February 2015, Pages 440–445

ترجمه کلمات کلیدی
مهار کننده های انتخابی بازجذب سروتونین؛ اختلال وسواس اجباری؛ فرزندان؛ رفتار؛ سندرم فعال سازی؛ کارآزمایی تصادفی کنترل شده
کلمات کلیدی انگلیسی
Selective serotonin reuptake inhibitors; Obsessive-compulsive disorder; Children; Treatment; Activation syndrome; Randomized-controlled trial
پیش نمایش مقاله
پیش نمایش مقاله  بررسی آزمایشی اکتیگرافی به عنوان یک اقدام هدف از علائم فعال سازی SSRI: نمایش نتایج: از مطالعه درمان روان دارو شناسی پلاسبو با کنترل تصادفی

چکیده انگلیسی

Selective serotonin reuptake inhibitors (SSRIs) are an efficacious and effective treatment for pediatric obsessive-compulsive disorder (OCD) but have received scrutiny due to a potential side effect constellation called activation syndrome. While recent research introduced a subjective measure of activation syndrome, objective measures have not been tested. This pilot study, using data from a larger randomized-controlled trial, investigated the potential of actigraphy to provide an objective measure of activation symptoms in 44 youths with OCD beginning an SSRI medication regimen. Data were collected over the first four weeks of a multi-site, parallel, double-blind, randomized, placebo controlled psychopharmacological treatment study and statistical modeling was utilized to test how activation syndrome severity predicts daily and nightly activity levels. Results indicated that youths with higher activation symptoms had lower daytime activity levels when treatment averages were analyzed; in contrast youths who experienced onset of activation symptoms one week were more likely to have higher day-time and night-time activity ratings that week. Results support actigraphy as a potential objective measure of activation symptoms. Subsequent studies are needed to confirm these findings and test clinical applications for use by clinicians to monitor activation syndrome during SSRI treatment. National Institutes of Health (5UO1 MH078594-01); NCT00382291.