دانلود مقاله ISI انگلیسی شماره 140572
ترجمه فارسی عنوان مقاله

محور مغز گوته ماهی: ماهی قزل آلای رنگین کمان با پاسخ کم و کورتیزول بالا تفاوت های ذاتی در سلامت روده و بیان ژن مغز را نشان می دهد

عنوان انگلیسی
The brain-gut axis of fish: Rainbow trout with low and high cortisol response show innate differences in intestinal integrity and brain gene expression
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
140572 2018 39 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : General and Comparative Endocrinology, Volume 257, 1 February 2018, Pages 235-245

پیش نمایش مقاله
پیش نمایش مقاله  محور مغز گوته ماهی: ماهی قزل آلای رنگین کمان با پاسخ کم و کورتیزول بالا تفاوت های ذاتی در سلامت روده و بیان ژن مغز را نشان می دهد

چکیده انگلیسی

In fish, the stress hormone cortisol is released through the action of the hypothalamic pituitary interrenal axis (HPI-axis). The reactivity of this axis differs between individuals and previous studies have linked this to different behavioural characteristics and stress coping styles. In the current study, low and high responding (LR and HR) rainbow trout in terms of cortisol release during stress were identified, using a repeated confinements stress test. The expression of stress related genes in the forebrain and the integrity of the stress sensitive primary barrier of the intestine was examined. The HR trout displayed higher expression levels of mineralocorticoid and serotonergic receptors and serotonergic re-uptake pumps in the telencephalon during both basal and stressed conditions. This confirms that HPI-axis reactivity is linked also to other neuronal behavioural modulators, as both the serotonergic and the corticoid system in the telencephalon are involved in behavioural reactivity and cognitive processes. Involvement of the HPI-axis in the brain-gut-axis was also found. LR trout displayed a lower integrity in the primary barrier of the intestine during basal conditions compared to the HR trout. However, following stress exposure, LR trout showed an unexpected increase in intestinal integrity whereas the HR trout instead suffered a reduction. This could make the LR individuals more susceptible to pathogens during basal conditions where instead HR individuals would be more vulnerable during stressed conditions. We hypothesize that these barrier differences are caused by regulation/effects on tight junction proteins possibly controlled by secondary effects of cortisol on the intestinal immune barrier or differences in parasympathetic reactivity.