ملاتونین شروع سریع و اثر طولانی مدت در کاهش رفتارهای افسردگی را در موش های بالغ که به علت استرس خفیف غیر قابل پیش بینی مزمن

The results indicate that not only does melatonin induce an antidepressant-like action within this rat model of depression, but does so with a rapid onset and prolonged efficacy. As most current treatments for depression require an extended period of administration, our current results suggest that melatonin may prove to be a particularly effect agent to promote a rapid onset and prolonged behavioral benefits in the treatment of depression.