یک مطالعه سنجشی حمله خواب Ullanlinna در هنگ کنگ چین
|کد مقاله||سال انتشار||تعداد صفحات مقاله انگلیسی||ترجمه فارسی|
|30148||2000||7 صفحه PDF||سفارش دهید|
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Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Journal of Psychosomatic Research, Volume 49, Issue 5, November 2000, Pages 355–361
Objective: To validate the Chinese version of Ullanlinna Narcolepsy Scale (CUNS). Methods: A total of 234 subjects [163 male (69.7%) and 71 female (30.3%)] including 17 patients with narcolepsy, 21 normal controls and 196 patients with various sleep and psychiatric disorders were studied. The diagnoses of these patients were independently ascertained with sleep laboratory confirmation whenever indicated. All the subjects were interviewed through the telephone by a trained lay interviewer who was blind to the diagnosis. The questionnaire included demographic information, sleep habits and CUNS. Results: Narcoleptic patients had a significantly higher CUNS score (18.6±4.7; 95% confidence interval (CI) 16.2–21.0) and differentiated well from all the other groups (F6,227=28.4, P<0.001). The CUNS has a satisfactory internal consistency with Cronbach's alpha of 0.75. The principal component analysis with varimax rotation revealed two factors, namely sleepiness and cataplexy factors, which accounted for 45.5% of the total variance. The best cut-off point for the CUNS scale was found to be at 13/14 with high specificity (93.5%), sensitivity (94.1%), negative predictive value (NPV, 99.5%) and modest positive predictive value (PPV, 53.3%). The AUC of receiver operating characteristic (ROC) analysis was 0.97 (95% CI 0.95–0.99). Conclusions: The CUNS was validated with satisfactory psychometric properties. The cross-cultural validation of UNS scale suggested that it could be used across the ethnic groups.
Sleep disorders are common but under-recognized and under-treated. Excessive daytime sleepiness (EDS), in particular, is a frequent clinical problem and as many as 5% of general population might be suffering from it  and . The causes of EDS are numerous ranging from the more frequent sleep deprivation, sleep–wake schedule disturbance, drug/alcohol effects and sleep-related breathing disorders to relatively rarer but perhaps more disabling narcolepsy. Characterized by EDS, cataplexy, nocturnal sleep disturbance and other REM sleep-related phenomenon such as sleep paralysis and hypnagogic hallucination, clinically, narcolepsy is a lifelong crippling sleep disorder with conspicuous physical and psychosocial complications , ,  and . Recent research suggested that narcolepsy has more marked academic and occupational difficulties, negative socioeconomic impact and crippling effect on daily life than other chronic medical disorders such as epilepsy  and . Although the exact etiology is unknown, both genetic and possibly ethnic and environmental factors are believed to play an important part  and . It has been estimated that the prevalence rate of narcolepsy in general population varies from 0.59% in Japanese to 0.00023% in Israel Jews , ,  and . One of the major reasons for such nearly 2500-fold difference in the prevalence rate was clearly related to the differences in the methodology and studying population, but possible ethnic predisposition cannot be excluded . Similar data on Chinese narcolepsy has been even more limited. Based on our clinical and laboratory data, the estimated rate of narcolepsy in Hong Kong Chinese population was projected to be ranging from 0.04% to 0.001%  and . Alternatively, based on the suggestion that the prevalence rate of narcolepsy is closely related to the frequency of human leukocyte antigen (HLA) typing (like DR2, DQ1) in the general population, then the similar prevalence of HLA typing between Chinese and Japanese should suggest a similarly high prevalence of narcolepsy among Chinese subjects  and . Hence, it is clear that a definitive account of prevalence of narcolepsy in Chinese could only come from a well-designed epidemiological study together with sleep laboratory confirmation. One of the major limitations in clarifying the controversy of the exact prevalence of narcolepsy across the globe has been the lack of availability of a convenient and suitable screening tool to detect the presence of narcolepsy in a large population. To date, the best estimation of population prevalence rate came from the Finnish twin cohort study with 11,354 subjects. By using the screening questionnaire [Ullanlinna Narcolepsy Scale (UNS)] at the initial stage and then followed by the phone interviews, polysomnography and HLA typing of selected subjects; they reported a population prevalence rate of 0.026% (95% CI 0.0–0.06) in Finland  and . The UNS was an 11-item scale that investigated the subjects' two main aspects of narcolepsy, namely abnormal sleep tendency and cataplexy. Four main stem questions about daytime sleepiness (45.5% of the total score), napping (9.0%), nocturnal sleep latency (9.0%) and cataplexy-related questions (36.5%) will be asked and the scale has a range of scores from 0 to 44  and . The Finnish study suggested that the scale was very sensitive (100%) and specific (98.8%) for screening narcolepsy  and . However, as suggested by the authors, this simple but very useful questionnaire needed to be replicated and validated in other ethnic populations  and . In addition, the scale has not been subjected to rigorous statistical analysis, which limited the interpretation of the validity and reliability of the scale  and .
نتیجه گیری انگلیسی
Demographic data of the subjects were presented in Table 1. In our study, there were more male (69.7%) than female (30.3%) subjects. There was age difference among the groups (F6,227=28.4, P<0.001). Post hoc analyses using Tukey's HSD tests indicated that there was not much difference in age when comparing narcolepsy groups with other groups except severe SAS (P=0.04) and RSBD patients (P<0.05).