رفتار تکانشی و متغیرهای بالینی همراه در بیماری پارکینسون

Background Parkinson's disease (PD) is a degenerative brain disorder accompanied by the loss of dopaminergic neurons and the presence of motor and non-motor symptoms. Objective We performed a cross-sectional, questionnaire-based analysis of impulsive behavior in our PD clinic population to assess prevalence and associated characteristics. Results We found a higher prevalence of impulsive behavior (29.7%) than previously reported, and found multiple, concurrent impulsive behaviors in 26% of subjects reporting impulsive behavior. Conclusions Our findings contribute to the growing awareness of impulsive behavior in PD, and support the need for longitudinal studies to assess changes in impulsive behaviors in Parkinson's patients.

Impulse control disorders are a group of disorders, including pathological gambling, hypersexuality, and compulsive shopping, which are characterized by compulsive engagement in a behavior despite adverse consequences, diminished control over the problematic behavior, and an urge prior to, and a hedonic sense during, performance of the behavior.1 Impulse control disorders have been recently described in patients with Parkinson's disease (PD).2, 3 and 4 It remains unclear, however, whether these impulse control disorders or impulsive behaviors are a consequence of the disease itself, due to underlying personality traits,5 are secondary to the pharmacological management of the disease,3 or a complex interplay of all these factors.2 and 6