تحویل نیکوتین تریدرمانی مبتنی بر غشای نانولوله کربنی قابل برنامه ریزی با آزمون اعتبار سنجی میکرو دیالیز

Carbon nanotube (CNT) membranes have the ability to be switched by small applied bias and can improve smoking cessation therapy by the transdermal delivery of a variable nicotine flux/dose as set by remote therapy. However, a new transdermal assay need to be developed to show switching events of such devices. A microdialysis membrane probe was placed beneath porcine skin on the flow cell apparatus to capture nicotine molecules for flux analysis showing 6–8 times increase in nicotine level with device in on state and 3 times that of commercially available Nicoderm. This study for the first time demonstrates the feasibility of a microdialysis method for demonstrating switchable transdermal drug delivery devices.Download high-res image (161KB)Download full-size image