بهینه سازی طراحی انطباق برای آزمایشهای دوزهای مرحله 2 که شامل موفقیتهای طولانی مدت و ملاحظات مالی است: مطالعه موردی برای درد نوروپاتیک

In this paper, we propose an adaptive randomization design for Phase 2 dose-finding trials to optimize Net Present Value (NPV) for an experimental drug. We replace the traditional fixed sample size design (Patel, et al., 2012) by this new design to see if NPV from the original paper can be improved. Comparison of the proposed design to the previous design is made via simulations using a hypothetical example based on a Diabetic Neuropathic Pain Study.