دانلود مقاله ISI انگلیسی شماره 161685
ترجمه فارسی عنوان مقاله

ارتباط میان ضعف و اجزای فردی آن با خطر افتادن در بیماران مبتلا به اختلالات طیفی اسکیزوفرنی

عنوان انگلیسی
Association between frailty and its individual components with the risk of falls in patients with schizophrenia spectrum disorders
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
161685 2018 6 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Schizophrenia Research, Available online 1 February 2018

ترجمه کلمات کلیدی
سن پیشرفت، اسکیزوفرنی مزمن، سقوط، سرماخوردگی عدم فعالیت فیزیکی،
کلمات کلیدی انگلیسی
Accelerated age; Chronic schizophrenia; Falls; Frailty; Physical inactivity;
پیش نمایش مقاله
پیش نمایش مقاله  ارتباط میان ضعف و اجزای فردی آن با خطر افتادن در بیماران مبتلا به اختلالات طیفی اسکیزوفرنی

چکیده انگلیسی

Frailty is common among older people who carry an increased risk for poor outcomes, including falls, physical disabilities, infections, and mortality. However, the prevalence of frailty and the prognostic influence of frailty status are poorly understood in adults with schizophrenia. The present study aimed to assess the predictive ability of frailty and its individual components for the risk of falls in patients with chronic schizophrenia. Frailty status was assessed at baseline by using Fried frailty criteria after the enrollment of 561 patients with chronic schizophrenia. The patients were followed up for 18 months, and the outcome of the study was the incidence of falls. The mean age of the patients was 53.8 years, and a total of 35.3% were females. One-quarter (25.3%) of patients received typical antipsychotics. The prevalence of frailty was 10.2% at baseline. During follow-up, 40 patients (7.1%) experienced falls. Frailty status was associated with increased susceptibility to falling with an unadjusted hazard ratio of 5.27 (95% confidence interval: 2.75–10.10) and a hazard ratio of 4.65 (95% confidence interval: 1.88–11.54) after multivariate adjustment. Among the components of frailty, the most significant association was observed between low physical activity and falls (p < 0.05). In conclusion, frailty is highly prevalent in patients with chronic schizophrenia and is associated with the risk of adverse clinical events. Further studies are needed to explore the mechanisms underlying the relationship between schizophrenia and frailty in an attempt to develop an appropriate treatment plan for improving clinical outcomes for these patients.