کمبود نامگذاری برای آیتم های غیرزنده: مطالعه عصب روانشناختی و PET
|کد مقاله||سال انتشار||تعداد صفحات مقاله انگلیسی||ترجمه فارسی|
|29942||1997||9 صفحه PDF||سفارش دهید|
نسخه انگلیسی مقاله همین الان قابل دانلود است.
هزینه ترجمه مقاله بر اساس تعداد کلمات مقاله انگلیسی محاسبه می شود.
این مقاله تقریباً شامل 6524 کلمه می باشد.
هزینه ترجمه مقاله توسط مترجمان با تجربه، طبق جدول زیر محاسبه می شود:
|شرح||تعرفه ترجمه||زمان تحویل||جمع هزینه|
|ترجمه تخصصی - سرعت عادی||هر کلمه 90 تومان||10 روز بعد از پرداخت||587,160 تومان|
|ترجمه تخصصی - سرعت فوری||هر کلمه 180 تومان||5 روز بعد از پرداخت||1,174,320 تومان|
Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)
Journal : Neuropsychologia, Volume 35, Issue 3, 7 February 1997, Pages 359–367
We report a patient with progressive left hemisphere atrophy who presented a lexical retrieval deficit more pronounced in naming non-living items than in naming living items. Word frequency and familiarity strongly influenced the performance, but the dissociation persisted when the items were controlled for these factors. In addition, the prevalent deficit for non-living items in respect to living items could be confirmed in tasks where other patients presented the opposite pattern. A PET study showed a significant hypometabolism in the left hemisphere regions suggesting that, at variance with living deficit which is observed in patients with bilateral lesions, non-living deficit is produced by unilateral left hemispheric lesions. This patient confirms that living and non-living categories may dissociate and that distinct neural systems subsume their knowledge. Copyright©1996 Elsevier Science Ltd.
Instances of patients with selective impairment for semantic categories in naming and in visual identification have been repeatedly reported. The vast majority of these observations concerns patients with a prevalent deficit for natural biological categories in respect to artefactual objects 1, 7, 8, 24, 28, 30 and 32. Different hypotheses have been put forward to explain this dissociation: the visual similarity among components of natural categories that makes them difficult to discriminate ; a loss of structural knowledge critical to distinguish natural items in respect to artefactual items which could be better defined on the basis of functional attributes 1, 7, 28, 30 and 39; the categorical organisation of the lexicon . Recently, the genuineness of this dissociation has been put under discussion. The prevalent impairment of natural categories has been considered as a spurious effect due to the fact that natural items belong to lower range of familiarity or name frequency or have a higher visual complexity in respect to artefacts 13 and 34. However, the hypothesis of a category specific semantic impairment for living items is still tenable for two main reasons: the prevalent impairment for natural items may persist when conjoint effects of visual familiarity, visual complexity and name frequency are controlled 9, 14 and 29and when the experimental design has sufficient power ; the selective category impairment has also been described, albeit less frequently, for categories of artefacts 2, 16, 27, 37 and 38. It has to be acknowledged however, that, in spite of the efforts made by various authors, it is virtually impossible to rule out all the possible biases due to stimulus selection. For example, Parkin and Stewart are not fully convinced of the stimuli selected by Sartori et al. . Although controlled along many variables, the sets of stimuli for living and non-living items selected by these authors may not be matched for featural overlap since living items shared more common features than non-living items, thus resulting to be more difficult to discriminate than non-living items. The existence of patients with a prevalent impairment for non-living items is more compelling in confirming a selective category deficit, since it demonstrates that the dissociation between living and non-living deficit is a double one, and even more convincing is the demonstration that the double dissociation between living and non-living may be obtained with the same set of stimuli ruling out any bias due to the stimulus selection. Patients with a prevalent impairment for non-living items are quite rare. Warrington and McCarthy described a patient who presented residual verbal comprehension for objects; food, animals and flowers were relatively preserved. The same authors described a second patient with poor verbal comprehension of objects as compared to food and living things and among objects, a more severe deficit for small, manipulable objects as compared to large objects. Further evidence is provided by Hillis and Caramazza and by Sacchett and Humphreys who described patients with a prevalent deficit for artefacts in naming and in word–picture matching tasks. Independent evidence in support of the genuinenesss of a selective categorical deficit for living and non-living items comes from the observation that deficits for the former or the latter categories are likely to be related to different lesion sites in the brain. Patients with prevalent impairments for living things have bilateral inferior temporal lesions (see for discussion), while prevalent impairment for non-living items are usually produced by ischaemic lesion involving the territory of the left middle cerebral artery 27, 37 and 38. A recent PET activation experiment confirms these neuropathological data and suggests the segregation of neural substrates involved in the recognition of living and non-living items . In this study the authors measured the cerebral blood flow in normal subjects while they were deciding if pairs of visual stimuli were or were not different representations of the same animal or object. They showed that the recognition of animals activated the posterior temporo-occipital regions of the brain bilaterally, while the recognition of artefacts engaged a left hemisphere network, involving also the left dorsolateral frontal cortex. To summarise, we consider the available experimental evidence sufficient to confirm that the categorical dissociation between living and non-living items is genuine and may be subserved by brain structures involved in the processing of various kinds of information. However, we are aware of the possibility that aspecific factors, such as word frequency, familiarity and visual complexity, may contribute to producing or potentiating category dissociation. In this paper we describe a patient with a progressive focal left hemisphere atrophy, and a progressive pure naming deficit, prevalent for non-living items. This patient was requested to name items belonging to categories of living and non-living items, controlled for the above-mentioned variables that are known to influence performance. Among various tasks, particularly relevant was the administration of the naming tasks devised by Sartori et al. and Gainotti and Silveri , respectively, to explore in their patients the selective deficit for living items. This was to demonstrate, with the same set of stimuli, a double dissociation between living and non-living categories. The patient also underwent a [18F]FDG PET study in order to evaluate the functional metabolic correlation.
نتیجه گیری انگلیسی
Fig. 1(b) reports the SPM (Z) maps of the significant cerebral hypometabolism. The hypometabolic foci are reported in Table 3. These indicate the areas where cerebral metabolism is significantly reduced in comparison to the control group. The location of the hypometabolic regions is determined according to the stereotactic coordinates as resulted by SPM analysis; a significant hypometabolism (threshold for significance: Z score>3.8, P<0.0001) was found in the left middle temporal gyrus (Ba 21/38), left hippocampal (Ba 28/35) and parahippocampal gyrus (Ba 36/20). A severe hypometabolism was also detected in the inferior parietal lobule (Ba 40), consistent with marked atrophy shown on MRI.