دانلود مقاله ISI انگلیسی شماره 33745
ترجمه فارسی عنوان مقاله

ارتباط آسیب شناختی و تغذیه ای اسید وانیلیک پلاسمای انسان در نوجوانان مبتلا به بی اشتهایی عصبی

عنوان انگلیسی
Psychopathological and nutritional correlates of plasma homovanillic acid in adolescents with anorexia nervosa
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
33745 2008 8 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Journal of Psychiatric Research, Volume 42, Issue 3, February 2008, Pages 213–220

ترجمه کلمات کلیدی
بی اشتهایی عصبی - نوجوانان - دوپامین - بهبود وزن -
کلمات کلیدی انگلیسی
Anorexia nervosa; Adolescents; Homovanillic acid; pHVA; Dopamine; Weight recovery.
پیش نمایش مقاله
پیش نمایش مقاله  ارتباط آسیب شناختی و تغذیه ای اسید وانیلیک پلاسمای انسان در نوجوانان مبتلا به بی اشتهایی عصبی

Dopaminergic abnormalities have been described in anorexia nervosa but studies about plasma level of homovanillic acid (pHVA) have yielded conflicting results probably due to the small number and the heterogeneity of patients. Plasma HVA, nutritional and hormonal parameters and several scales – the Eating Attitudes Test (EAT), the Beck Depression Inventory (BDI), the Leyton Obsessional Inventory-child version (LOI-C) and the State and Trait Anxiety Inventory (STAI) – were assessed in 44 adolescent anorexia nervosa patients (mean age 14.7 years, SD 1.7) consecutively admitted to an Eating Disorder Unit. They were evaluated at admission, at discharge and, in 34 cases, after 9 months of follow-up. pHVA was also assessed in 16 control adolescents. Patients had significantly higher pHVA than controls (p = .002). About 31% of patients had a very high level of pHVA, a significantly higher (p = .006) mean score in the BDI and a non significantly higher mean score in the EAT. After weight recovery some laboratory parameters improved as well as the EAT (p = .019), the BDI (p = 001) and the Interference score of the LOI-C (p = .004). Moreover, pHVA decreased significantly (p = .036). At follow-up, patients with normal weight had lower (p = .037) pHVA than patients with low weight. The conclusion would be that there is a dopaminergic dysfunction in anorexic patients, specially in a subgroup with high depressive and anorexic symptomatology. With weight recovery and psychopathological improvement, pHVA tends to normalization.