دانلود مقاله ISI انگلیسی شماره 69500
ترجمه فارسی عنوان مقاله

استرس مزمن نوجوانی باعث هیپوتالاموآی هیپوفاتیا می شود. پاسخ هیپوپروتئینی عضلانی و رفتار افسردگی در موش های صحرایی ماده بالغ

عنوان انگلیسی
Adolescent chronic stress causes hypothalamo–pituitary–adrenocortical hypo-responsiveness and depression-like behavior in adult female rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
69500 2016 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychoneuroendocrinology, Volume 65, March 2016, Pages 109–117

ترجمه کلمات کلیدی
بلوغ، استرس متغیر مزمن، نورودنکروم، افسردگی، جوانی زن
کلمات کلیدی انگلیسی
Adolescence; Chronic variable stress; Neuroendocrine; Depression; Female rodent

چکیده انگلیسی

Adolescence is a period of substantial neuroplasticity in stress regulatory neurocircuits. Chronic stress exposure during this period leads to long-lasting changes in neuroendocrine function and emotional behaviors, suggesting adolescence may be a critical period for development of stress vulnerability. This study investigated the effects of exposure to 14 days of chronic variable stress (CVS) in late-adolescent (pnd 45–58) female rats on neuroendocrine function, neuropeptide mRNA expression and depressive-like behavior in adolescence (pnd 59) and in adulthood (pnd 101). Adult females exposed to CVS in adolescence have a blunted hypothalamo-pituitary-adrenocortical (HPA) axis in response to a novel stressor and increased immobility in the forced swim test. Blunted HPA axis responses were accompanied by reduced vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus (PVN), suggesting decreased central drive. Adolescent females tested immediately after CVS did not exhibit differences in stress reactivity or immobility in the forced swim test, despite evidence for enhanced central HPA axis drive (increased CRH mRNA expression in PVN). Overall, our study demonstrates that exposure to chronic stress in adolescence is sufficient to induce lasting changes in neuroendocrine drive and behavior, potentially altering the developmental trajectory of stress circuits as female rats age into adulthood.