دانلود مقاله ISI انگلیسی شماره 69511
ترجمه فارسی عنوان مقاله

نقش قشر اینسولار در مدل حساسیت احشایی در موش در معرض استرس مزمن

عنوان انگلیسی
Role of insular cortex in visceral hypersensitivity model in rats subjected to chronic stress
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
69511 2014 6 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 220, Issue 3, 30 December 2014, Pages 1138–1143

ترجمه کلمات کلیدی
اختلالات گوارشی عملکردی؛ سندرم روده تحریک پذیر؛ سوء هاضمه عملکردی؛ سوزش سر دل کاربردی؛ یبوست عملکردی؛ ACC، شکنج کمربندی قدامی؛ PFC، قشر جلو مغزی؛ IC، قشر اینسولار؛ VMR، احشایی پاسخ موتور؛ الکترومایوگرام؛ روده بزرگ اتساع رکتوم؛ سطح زیر منحنی در ثانیه؛ استرس جزئی قشر دیوار؛ حساسیت احشایی؛ استرس جزئی؛ اختلالات گوارشی عملکردی
کلمات کلیدی انگلیسی
FGIDs, functional gastrointestinal disorders; IBS, irritable bowel syndrome; FD, functional dyspepsia; FH, functional heartburn; FC, functional constipation; ACC, anterior cingulate gyrus; PFC, prefrontal cortex; IC, insular cortex; VMR, Visceral Motor Response; EMG, electromyogram; CRD, colon rectum distension; AUC/s, the area under the curve per second; NMDA, N-methyl-D-day (door) aspartate; PRS, partial restraint stressInsular cortex; Visceral hypersensitivity; Partial restraint stress; Functional gastrointestinal disorders
پیش نمایش مقاله
پیش نمایش مقاله  نقش قشر اینسولار در مدل حساسیت احشایی در موش در معرض استرس مزمن

چکیده انگلیسی

Abnormal processing of visceral sensation at the level of the central nervous system has been proven to be important in the pathophysiologic mechanisms of stress related functional gastrointestinal disorders. However, the specific mechanism is still not clear. The insular cortex (IC) was considered as one important visceral sensory area. Moreover, the IC has been shown to be involved in various neuropsychiatric diseases such as panic disorders and post-traumatic stress disorder. However, whether the IC is important in psychological stress related visceral hypersensitivity has not been studied yet. In our study, through destruction of the bilateral IC, we explored whether the IC played a critical role in the formation of visceral hypersensitivity induced by chronic stress on rats. Chronic partial restraint stress was used to establish viscerally hypersensitive rat model. Bilateral IC lesions were generated by N-methyl-D-day (door) aspartate. After a recovery period of 7 days, 14-day consecutive restraint stress was performed. The visceromotor response to colorectal distension was monitored by recording electromyogram to measure rats׳ visceral sensitivity. We found that bilateral insular cortex lesion could markedly inhibit the formation of visceral hypersensitivity induced by chronic stress. The insular cortex plays a critical role in the pathophysiology of stress-related visceral hypersensitivity.