ستون گل قوسی در توهمات شنوایی کلامی: یک متاآنالیز از مطالعات انتشار تانسور تصویربرداری

Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n = 106) and HCs (n = 150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg = − 0.42; CI[− 0.69,− 0.16]; p < 10− 3). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.

Auditory-verbal hallucinations (AVHs), i.e., hearing voices in the absence of external stimuli, can be observed trans-diagnostically, although they are notably present in the schizophrenia spectrum (SZ) (Jardri et al., 2013). These experiences were shown to be associated with an impaired connectivity of large-scale networks (Hoffman and Hampson, 2011 and Amad et al., 2014). Among the available methods to study neural connectivity, diffusion tensor imaging (DTI) specifically explores white matter integrity. This review presents the first meta-analysis (MA) of DTI studies conducted in participants with SZ suffering from AVHs compared with matched healthy controls (HCs). This review aimed to 1) identify the fiber bundles most consistently associated with AVHs and 2) determine the heterogeneity factors in the current literature in order to 3) develop reliable knowledge about AVHs and 4) provide recommendations for designing future DTI studies of the AVH phenomenon.