دانلود مقاله ISI انگلیسی شماره 117301
ترجمه فارسی عنوان مقاله

تشخیص چهره دیفرانسیل تشخیصی برای احساسات ضمنی منفی در اوتیسم و ​​اسکیزوفرنیا

عنوان انگلیسی
Transdiagnostic deviant facial recognition for implicit negative emotion in autism and schizophrenia
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
117301 2018 12 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 28, Issue 2, February 2018, Pages 264-275

پیش نمایش مقاله
پیش نمایش مقاله  تشخیص چهره دیفرانسیل تشخیصی برای احساسات ضمنی منفی در اوتیسم و ​​اسکیزوفرنیا

چکیده انگلیسی

Impaired facial affect recognition (FAR) is observed in schizophrenia and autism spectrum disorder (ASD) and has been linked to amygdala and fusiform gyrus dysfunction. ASD patient's impairments seem to be more pronounced during implicit rather than explicit FAR, whereas for schizophrenia data are inconsistent. However, there are no studies comparing both patient groups in an identical design. The aim of this three-group study was to identify (i) whether FAR alterations are equally present in both groups, (ii) whether they are present rather during implicit or explicit FAR, (iii) and whether they are conveyed by similar or disorder-specific neural mechanisms. Using fMRI, we investigated neural activation during explicit and implicit negative and neutral FAR in 33 young-adult individuals with ASD, 20 subjects with paranoid-schizophrenia and 25 IQ- and gender-matched controls individuals. Differences in activation patterns between each clinical group and controls, respectively were found exclusively for implicit FAR in amygdala and fusiform gyrus. In addition, the ASD group additionally showed reduced activations in medial prefrontal cortex (PFC), bilateral dorso-lateral PFC, ventro-lateral PFC, posterior-superior temporal sulcus and left temporo-parietal junction. Although subjects with ASD showed more widespread altered activation patterns, a direct comparison between both patient groups did not show disorder-specific deficits in neither patient group. In summary, our findings are consistent with a common neural deficit during implicit negative facial affect recognition in schizophrenia and autism spectrum disorders.