دانلود مقاله ISI انگلیسی شماره 119683
ترجمه فارسی عنوان مقاله

کاهش سطح فاکتور رشد فیبروبلاست سرم در کودکان مبتلا به اختلال طیف اوتیسم

عنوان انگلیسی
Decreased levels of serum fibroblast growth factor-2 in children with autism spectrum disorder
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
119683 2017 21 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 257, November 2017, Pages 79-83

ترجمه کلمات کلیدی
اختلال طیف اوتیسم، اتوپاتوژنز، عامل فیبروبلاست رشد 2، عامل فیبروبلاست پایه، توسعه قشر،
کلمات کلیدی انگلیسی
Autism spectrum disorder; Etiopathogenesis; Fibroblast growth factor-2; Basic fibroblast growth factor; Cortex development;
پیش نمایش مقاله
پیش نمایش مقاله  کاهش سطح فاکتور رشد فیبروبلاست سرم در کودکان مبتلا به اختلال طیف اوتیسم

چکیده انگلیسی

The neurodevelopment and functioning of the central nervous system, and especially the cerebral cortex, have basic importance to understand neuropsychiatric disorders like autism. Fibroblast growth factor-2 (FGF-2) plays a very important role in the development and functioning of the cortex. FGF-2 is related to developmental processes in the central nervous system such as neurogenesis, migration, differentiation and survival. This study researched the serum FGF-2 levels in children with autism spectrum disorder (ASD). With this aim, 60 ASD children and 40 healthy controls were compared. We applied a sociodemographic form and the Childhood Autism Rating Scale (CARS) to each subject with their family to assess the severity of autism. Additionally, all subjects had routine laboratory tests performed. Serum samples were studied with ELISA. The results found that serum FGF-2 levels were statistically significantly low in the patient group compared to the healthy control group (p value 0.003). Additionally there was a statistically significant negative correlation identified between serum FGF-2 levels and CARS score for all subjects (r = −0.300; p = 0.02). In conclusion, FGF-2 may contribute to the etiopathogenesis of ASD.