الگوهای آزادسازی دوپامین فیزیکی متمایز در استریاتوم در هنگام یادگیری برگشت پذیر

Together with our previous results obtained in the VMS, these findings reveal distinct phasic DA release patterns during adaptation of established behavior in DLS and VMS. The VMS DA signal, which is highly sensitive to reversal of response-reward contingences, may provide a teaching signal to guide reward-related learning and facilitate behavioral adaptation, whereas DLS DA may reflect a ‘response execution signal’ largely independent of outcome, that may be involved in initiation and energizing of operant behavior.