دانلود مقاله ISI انگلیسی شماره 126999
ترجمه فارسی عنوان مقاله

اختلاف حجمی زیر فرعی بین مراحل بالینی جوانان با اختلالات عاطفی و روانی

عنوان انگلیسی
Subcortical volumetric differences between clinical stages of young people with affective and psychotic disorders
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
126999 2018 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Volume 271, 30 January 2018, Pages 8-16

پیش نمایش مقاله
پیش نمایش مقاله  اختلاف حجمی زیر فرعی بین مراحل بالینی جوانان با اختلالات عاطفی و روانی

چکیده انگلیسی

The aim of this study was to investigate differences in subcortical and hippocampal volumes between healthy controls, young people at an early stage of affective and psychotic disorders and those in more advanced stages, to identify markers associated with functional outcomes and illness severity. Young people presenting to youth mental health services with admixtures of depressive, manic and psychotic symptoms (n = 141), and healthy counterparts (n = 49), aged 18–25 were recruited. Participants underwent magnetic resonance imaging, clinical assessments and were rated as to their current clinical stage. Eighty-four patients were classified at the attenuated syndrome stage (Stage 1b) and 57 were classified as having discrete and persistent disorders (Stage 2+). Automated segmentation was performed using NeuroQuant® to determine volumes of subcortical and hippocampus structures which were compared between groups and correlated with clinical and functional outcomes. Compared to healthy controls, Stage 2+ patients showed significantly reduced right amygdala volumes. Whereas Stage 1b patients showed significantly reduced left caudate volumes compared to healthy controls. Smaller left caudate volume correlated with greater psychological distress and impaired functioning. This study shows a clinical application for an automated program to identify and track subcortical changes evident in young people with emerging psychopathology.