سن در منارک سنی را در شروع اختلالات عاطفی و اضطرابی عمده پیش بینی می کند

Age at menarche in Sardinia, as elsewhere, has declined over the past decades. It was strongly associated with age at onset of bipolar and anxiety, as well as major depressive disorders across the age range, suggesting sustained effects of biological maturational factors.