افزایش واکنش استرس با نقص های شناختی همراه است و در مدل اختلالات عاطفی موش، عامل نوروتروفیک مشتق از مغز هیپوکامپ را کاهش می دهد

Our results demonstrate that HR mice exhibit hippocampus-dependent memory deficits along with decreased hippocampal, but not plasma, BDNF levels. Thus, the stress reactivity mouse lines are a promising animal model of the cognitive deficits in MD with the unique feature of a genetic predisposition for an altered HPA axis reactivity, which provides the opportunity to explore the progression of the symptoms of MD, predisposing genetic factors as well as new treatment strategies.