دانلود مقاله ISI انگلیسی شماره 125258
ترجمه فارسی عنوان مقاله

اختلال در تنظیم پیش فرنتال سیگنال های ارزش ذهنی استریاتال در روانپزشکی

عنوان انگلیسی
Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
125258 2017 16 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuron, Volume 95, Issue 1, 5 July 2017, Pages 221-231.e4

پیش نمایش مقاله
پیش نمایش مقاله  اختلال در تنظیم پیش فرنتال سیگنال های ارزش ذهنی استریاتال در روانپزشکی

چکیده انگلیسی

Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction, recent data suggest that aberrant decision making may also play an important role. Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclear. Here, we used a multi-modality functional imaging approach to identify these mechanisms in a population of adult male incarcerated offenders. Psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with weaker intrinsic functional connectivity between NAcc and ventromedial prefrontal cortex (vmPFC). NAcc-vmPFC connectivity strength was negatively correlated with NAcc subjective value-related activity; however, this putative regulatory pattern was abolished as psychopathy severity increased. Finally, weaker cortico-striatal regulation predicted more frequent criminal convictions. These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting the notion that reward system dysfunction comprises an important neurobiological risk factor.