دانلود مقاله ISI انگلیسی شماره 33983
ترجمه فارسی عنوان مقاله

ارتباط فیزیولوژی منطقه ای مغز و تکانشگری خصلتی، مهار حرکتی و کنترل اختلال نوشیدن بیش از حد

عنوان انگلیسی
Associations between regional brain physiology and trait impulsivity, motor inhibition, and impaired control over drinking
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
33983 2015 7 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research: Neuroimaging, Available online 7 May 2015

ترجمه کلمات کلیدی
- جریان خون مغزی - کنترل مهاری - توقف کار - الکل
کلمات کلیدی انگلیسی
Cerebral blood flow; fMRI; Inhibitory control; Stop task; Alcohol
پیش نمایش مقاله
پیش نمایش مقاله  ارتباط فیزیولوژی منطقه ای مغز و تکانشگری خصلتی، مهار حرکتی و کنترل اختلال نوشیدن بیش از حد

Trait impulsivity and poor inhibitory control are well-established risk factors for alcohol misuse, yet little is known about the associated neurobiological endophenotypes. Here we examined correlations among brain physiology and self-reported trait impulsive behavior, impaired control over drinking, and a behavioral measure of response inhibition. A sample of healthy drinkers (n=117) completed a pulsed arterial spin labeling (PASL) scan to quantify resting regional cerebral blood flow (rCBF), as well as measures of self-reported impulsivity (Eysenck I7 Impulsivity scale) and impaired control over drinking. A subset of subjects (n=40) performed a stop signal task during blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging to assess brain regions involved in response inhibition. Eysenck I7 scores were inversely related to blood flow in the right precentral gyrus. Significant BOLD activation during response inhibition occurred in an overlapping right frontal motor/premotor region. Moreover, impaired control over drinking was associated with reduced BOLD response in the same region. These findings suggest that impulsive personality and impaired control over drinking are associated with brain physiology in areas implicated in response inhibition. This is consistent with the idea that difficulty controlling behavior is due in part to impairment in motor restraint systems.