دانلود مقاله ISI انگلیسی شماره 69822
ترجمه فارسی عنوان مقاله

اختلالات تشخیص چهره عاطفی و اثرات دارو در پیش آشکاری از طریق بیماری هانتینگتون مرحله دوم

عنوان انگلیسی
Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington's disease
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
69822 2013 9 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 207, Issues 1–2, 15 May 2013, Pages 118–126

ترجمه کلمات کلیدی
حالات چهره؛ چهره ها؛ نورولپتیک؛ سروتونین؛ عصبی
کلمات کلیدی انگلیسی
Facial expressions; Faces; Neuroleptic; Serotonin; Neurodegenerative
پیش نمایش مقاله
پیش نمایش مقاله  اختلالات تشخیص چهره عاطفی و اثرات دارو در پیش آشکاری از طریق بیماری هانتینگتون مرحله دوم

چکیده انگلیسی

Facial emotion recognition impairments have been reported in Huntington's disease (HD). However, the nature of the impairments across the spectrum of HD remains unclear. We report on emotion recognition data from 344 participants comprising premanifest HD (PreHD) and early HD patients, and controls. In a test of recognition of facial emotions, we examined responses to six basic emotional expressions and neutral expressions. In addition, and within the early HD sample, we tested for differences on emotion recognition performance between those ‘on’ vs. ‘off’ neuroleptic or selective serotonin reuptake inhibitor (SSRI) medications. The PreHD groups showed significant (p<0.05) impaired recognition, compared to controls, on fearful, angry and surprised faces; whereas the early HD groups were significantly impaired across all emotions including neutral expressions. In early HD, neuroleptic use was associated with worse facial emotion recognition, whereas SSRI use was associated with better facial emotion recognition. The findings suggest that emotion recognition impairments exist across the HD spectrum, but are relatively more widespread in manifest HD than in the premanifest period. Commonly prescribed medications to treat HD-related symptoms also appear to affect emotion recognition. These findings have important implications for interpersonal communication and medication usage in HD.