دانلود مقاله ISI انگلیسی شماره 126822
ترجمه فارسی عنوان مقاله

اثر عصبی وابسته به جنسیت اکسی توسین در طول پردازش زیر محور چهره هیجان منفی

عنوان انگلیسی
Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
126822 2017 46 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : NeuroImage, Volume 162, 15 November 2017, Pages 127-137

ترجمه کلمات کلیدی
اکسی توسین، احساسات چهره، تفاوت جنسی، قشر ساق پا، گریوس فرونتال پایین اضطراب،
کلمات کلیدی انگلیسی
Oxytocin; Face emotion; Sex difference; Cingulate cortex; Inferior frontal gyrus; Anxiety;
پیش نمایش مقاله
پیش نمایش مقاله  اثر عصبی وابسته به جنسیت اکسی توسین در طول پردازش زیر محور چهره هیجان منفی

چکیده انگلیسی

In line with animal models indicating sexually dimorphic effects of oxytocin (OXT) on social-emotional processing, a growing number of OXT-administration studies in humans have also reported sex-dependent effects during social information processing. To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86–43 males) with a backward-masking emotional face paradigm. Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women. In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety. On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT. Our findings demonstrate that OXT produces sex-dependent effects even at the early stages of social-emotional processing, and suggest that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Thus in a therapeutic context OXT may potentially produce different effects on anxiety disorders in men and women.