مهار فسفودی استراز 7 بر بیان هورمون آزاد کننده تیروتروپین و هیپوتالاموس، تغذیه و اضطراب موش صحرایی اثر می گذارد

PDE7 inhibitor induced anxiolytic and anorexigenic like behavior depending on the dose used. Results supported hypothalamic TRH mediated feeding-reduction effects, and accumbal TRH mediation of inhibitor-induced anxiolysis. Thus, an i.p dose of this inhibitor might be reducing anxiety with no change in feeding, which could be useful for obese patients.