دانلود مقاله ISI انگلیسی شماره 155197
ترجمه فارسی عنوان مقاله

کمبود شناختی در بیماران مبتلا به اسکیزوفرنی پارانوئیدی: همبستگی بالینی و آزمایشگاهی آن است

عنوان انگلیسی
Cognitive deficit in patients with paranoid schizophrenia: Its clinical and laboratory correlates
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
155197 2018 25 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Psychiatry Research, Volume 262, April 2018, Pages 542-548

پیش نمایش مقاله
پیش نمایش مقاله  کمبود شناختی در بیماران مبتلا به اسکیزوفرنی پارانوئیدی: همبستگی بالینی و آزمایشگاهی آن است

چکیده انگلیسی

The aim of this study was to search for correlates of cognitive impairment in patients with paranoid schizophrenia among clinical, demographic, anamnestic and biochemical markers (NSE, S100B protein, BDNF, hs-CRP). Patients with paranoid schizophrenia (n=125) were examined using the Brief Assessment of Cognitive Function in Schizophrenia, the Rey-Osterrieth Complex Figure task, and a number of clinical scales including the Positive and Negative Syndrome Scale. The majority of patients demonstrated cognitive impairment. The type of impairment was highly heterogeneous and individual. Relationships were found between the degree of executive functioning and family history of mental illness; working memory and age of onset of schizophrenia; and visual memory and psychopathological symptomatology. Negative and affective symptoms were not significantly associated with cognitive functioning. Treatment with first generation antipsychotics was associated with a more frequent impairment of motor skills, and concomitant anticholinergic drugs, with reduced accuracy. Use of second-generation antipsychotics only was associated with better accuracy, working memory and speech fluency. Among the patients, 21.4% had signs of a systemic inflammatory response, indicating a possible role of inflammatory response in the development of schizophrenia. CRP, S100B and NSE levels reflected features of the course of illness and therapeutic response. Patients with lower concentrations of BDNF were characterized by lower processing speeds.