دانلود مقاله ISI انگلیسی شماره 155237
ترجمه فارسی عنوان مقاله

تفاوت جنسی در اثرات کافئین قبل و بعد از تولد بر رفتار و پروتئین های سیناپسی در موش های نابالغ

عنوان انگلیسی
Sex differences in the effects of pre- and postnatal caffeine exposure on behavior and synaptic proteins in pubescent rats
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
155237 2018 45 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 81, 2 February 2018, Pages 416-425

ترجمه کلمات کلیدی
کافئین، رفتار - اخلاق، توسعه مغز، بلوغ، تفاوت های جنسی،
کلمات کلیدی انگلیسی
Caffeine; Behavior; Brain development; Puberty; Sex differences;
پیش نمایش مقاله
پیش نمایش مقاله  تفاوت جنسی در اثرات کافئین قبل و بعد از تولد بر رفتار و پروتئین های سیناپسی در موش های نابالغ

چکیده انگلیسی

Few studies have addressed the effects of caffeine in the puberty and/or adolescence in a sex dependent manner. Considering that caffeine intake has increased in this population, we investigated the behavioral and synaptic proteins changes in pubescent male and female rats after maternal consumption of caffeine. Adult female Wistar rats started to receive water or caffeine (0.1 and 0.3 g/L in drinking water; low and moderate dose, respectively) during the active cycle at weekdays, two weeks before mating. The treatment lasted up to weaning and the offspring received caffeine until the onset of puberty (30–34 days old). Behavioral tasks were performed to evaluate locomotor activity (open field task), anxious-like behavior (elevated plus maze task) and recognition memory (object recognition task) and synaptic proteins levels (proBDNF, BDNF, GFAP and SNAP-25) were verified in the hippocampus and cerebral cortex. While hyperlocomotion was observed in both sexes after caffeine treatment, anxiety-related behavior was attenuated by caffeine (0.3 g/L) only in females. While moderate caffeine worsened recognition memory in females, an improvement in the long-term memory was observed in male rats for both doses. Coincident with memory improvement in males, caffeine increased pro- and BDNF in the hippocampus and cortex. Females presented increased proBDNF levels in both brain regions, with no effects of caffeine. While GFAP was not altered, moderate caffeine intake increased SNAP-25 in the cortex of female rats. Our findings revealed that caffeine promoted cognitive benefits in males associated with increased BDNF levels, while females showed less anxiety. Our findings revealed that caffeine promotes distinct behavioral outcomes and alterations in synaptic proteins during brain development in a sex dependent manner.