رابطه بین افسردگی و رفاه ذهنی در بیماران مبتلا به اسکیزوفرنیا تازه وارد

Background Depressive symptoms are common in schizophrenia and are considered core features of the disorder. The purpose of the present study was to examine the relationship between depressive symptoms and subjective well-being in newly admitted patients with schizophrenia. Methods Eighty newly admitted patients were comprehensively evaluated for subjective well-being, schizophrenic symptoms, and depressive symptoms using the Subjective Well-Being Under Neuroleptics Scale (SWN), the Positive and Negative Syndrome Scale (PANSS), and the Beck Depression Inventory. Correlation coefficients were obtained between depressive symptoms and subjective well-being while controlling for the influence of the severity of psychotic symptoms, extrapyramidal side effect, and subjective attitude toward antipsychotics, as assessed by the PANSS, the Drug-Induced Extrapyramidal Symptoms Scale, and the Drug Attitude Inventory, respectively. Results The SWN score had a significant negative correlation with the PANSS depression factor score (P < .001). Correlation analysis also revealed a significant negative correlation between the SWN score and the Beck Depression Inventory score (P < .001). Conclusions The results of our study suggest that depressive symptoms are significantly associated with a low subjective well-being in newly admitted patients with schizophrenia and that the relationship is significant even after controlling for the influence of potential confounding variables. Detection and appropriate management of depressive symptoms in schizophrenic patients may affect their perceptions of their own well-being.

Depressive symptoms are common in schizophrenia and are considered core features of the disorder [1] and [2]. Previous studies have shown a high prevalence of comorbid depressive symptoms in patients with schizophrenia, ranging up to 75% [2], [3], [4], [5] and [6]. Depressive symptoms in schizophrenia have often been associated with worse outcome, poor psychosocial functioning, higher rates of relapse, and suicidality [2]. Depression in schizophrenia has recently been readdressed because it has been suggested that atypical antipsychotics have beneficial effects on affective symptoms in addition to antipsychotic activity, which may be partly attributable to their favorable profile for extrapyramidal side effect, akathisia, and antipsychotic-induced dysphoria [2], [7], [8], [9], [10] and [11]. With regard to subjective well-being or quality of life, previous studies have shown that depressive symptoms are associated with a low quality of life in schizophrenia [12], [13], [14] and [15], suggesting that detection and appropriate treatment of depressive symptoms in schizophrenic patients may affect the perceptions of their own well-being. However, previous studies mainly focused the relationship in clinically stable outpatients, and the results may not be generalized to inpatients with acute exacerbation. It has been increasingly recognized that subjective well-being is a specific measurable parameter [16], [17], [18], [19], [20] and [21] and that most schizophrenic patients, if not experiencing severe cognitive impairment, are able to represent their subjective well-being [18], [19], [22], [23] and [24]. Hence, the purpose of the present study was to examine the relationship between depressive symptoms and subjective well-being in newly admitted patients to contribute to the growing interest in depressive symptoms of schizophrenia.