دانلود مقاله ISI انگلیسی شماره 36255
ترجمه فارسی عنوان مقاله

آشناپنداری در صرع لوب تمپورال: الگوی متابولیک دخالت قشر مغز در بیماران با ام آر آی طبیعی مغز

عنوان انگلیسی
Déjà-vu in temporal lobe epilepsy: Metabolic pattern of cortical involvement in patients with normal brain MRI
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
36255 2010 8 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuropsychologia, Volume 48, Issue 7, June 2010, Pages 2174–2181

ترجمه کلمات کلیدی
تشنج - شناخت - میزان سوخت و ساز مغزی برای قند -
کلمات کلیدی انگلیسی
Seizure; Recognition; PET; FDG; Cerebral metabolic rate for glucose; SPM
پیش نمایش مقاله
پیش نمایش مقاله  آشناپنداری در صرع لوب تمپورال: الگوی متابولیک دخالت قشر مغز در بیماران با ام آر آی طبیعی مغز

To contribute to the identification of brain regions involved in déjà-vu, we studied the metabolic pattern of cortical involvement in patients with seizures of temporal lobe origin presenting with or without déjà-vu. Using voxel-based analysis of 18FDG-PET brain scans, we compared glucose metabolic rate of 8 patients with déjà-vu, 8 patients without déjà-vu, and 20 age-matched healthy subjects. Patients were selected after comprehensive non-invasive presurgical evaluation, including normal brain MRI and surface electroclinical features compatible with unilateral temporal lobe epilepsy (TLE). Patients with and without déjà-vu did not differ in terms of age, gender, epilepsy lateralization, epilepsy onset, epilepsy duration, and other subjective ictal manifestations. TLE patients with déjà-vu exhibited ipsilateral hypometabolism of superior temporal gyrus and of parahippocampal region, in the vicinity of perirhinal/entorhinal cortex, in comparison either to healthy subjects or to TLE patients without déjà-vu (p < 0.05 FDR-corrected). By contrast, no difference was found between patient subgroups for hypometabolism of hippocampus and amygdala. At an individual-level, in comparison to healthy subjects, hypometabolism of both parahippocampal region and superior temporal gyrus was present in 7/8 patients with déjà-vu. Hippocampal metabolism was spared in 3 of these 7 patients.