جداسازی مادران نوزاد منجر به تضعیف حساسیت مکانیکی و حرارتی مرتبط با التهاب در موش های جوان

The open field test and the corticosterone measures showed no effect of MS. MS did not change mechanical thresholds prior to inflammation but reduced mechanical hyperalgesia after CFA-injection. MS animals did however present shorter latencies to display nocifensive behaviors compared to controls (CON). Furthermore, in CON but not MS, the repetitive noxious heat testing induced a decrease in reaction latencies. Moreover, MS dampened CFA-induced heat hyperalgesia. Altogether, our results suggest that ELS may have a protective impact on inflammatory pain.