دانلود مقاله ISI انگلیسی شماره 160224
ترجمه فارسی عنوان مقاله

آمیگدالا ناحیه پشتی می تواند تأثیر حافظه ترس بر خواب را مستقل از رفتار ترس و پاسخ استرس محیطی

عنوان انگلیسی
The basolateral amygdala can mediate the effects of fear memory on sleep independently of fear behavior and the peripheral stress response
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
160224 2017 31 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 137, January 2017, Pages 27-35

پیش نمایش مقاله
پیش نمایش مقاله  آمیگدالا ناحیه پشتی می تواند تأثیر حافظه ترس بر خواب را مستقل از رفتار ترس و پاسخ استرس محیطی

چکیده انگلیسی

Fear conditioning associated with inescapable shock training (ST) and fearful context re-exposure (CR) alone can produce significant behavioral fear, a stress response and alterations in subsequent REM sleep. These alterations may vary among animals and are mediated by the basolateral nucleus of the amygdala (BLA). Here, we used the GABAA agonist, muscimol (Mus), to inactivate BLA prior to CR and examined the effects on sleep, freezing and stress-induced hyperthermia (SIH). Wistar rats (n = 28) were implanted with electrodes for recording sleep, data loggers for recording core body temperature, and with cannulae aimed bilaterally into BLA. After recovery, the animals were habituated to the injection procedure and baseline sleep was recorded. On experimental day 1, rats received ST (20 footshocks, 0.8 mA, 0.5 s duration, 60 s interstimulus interval). On experimental day 7, the rats received microinjections (0.5 μl) into BLA of either Mus (1.0 μM; n = 13) or vehicle (Veh; n = 15) prior to CR (CR1). On experimental day 21, the animals experienced a second CR (CR2) without Mus. For analysis, the rats were separated into 4 groups: (Veh-vulnerable (Veh-Vul; n = 8), Veh-resilient (Veh-Res; n = 7), Mus-vulnerable (Mus-Vul; n = 7), and Mus-resilient (Mus-Res; n = 6)) based on whether or not REM was decreased, compared to baseline, during the first 4 h following ST. Pre-CR1 inactivation of BLA did not alter freezing or SIH, but did block the reduction in REM in the Mus-Vul group compared to the Veh-Vul group. These data indicate that BLA is an important region for mediating the effects of fearful memories on sleep.