دانلود مقاله ISI انگلیسی شماره 71565
ترجمه فارسی عنوان مقاله

نقشه برداری تثبیت حافظه ترس و بیان انقراض خاص JunB

عنوان انگلیسی
Mapping fear memory consolidation and extinction-specific expression of JunB
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
71565 2015 7 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neurobiology of Learning and Memory, Volume 125, November 2015, Pages 106–112

ترجمه کلمات کلیدی
حافظه ترس زمینه ؛ تثبیت؛ انقراض؛ JunB؛ AP-1
کلمات کلیدی انگلیسی
Context fear memory; Consolidation; Extinction; JunB; AP-1
پیش نمایش مقاله
پیش نمایش مقاله  نقشه برداری تثبیت حافظه ترس و بیان انقراض خاص JunB

چکیده انگلیسی

Understanding the molecular and cellular process specifically regulated during fear memory consolidation and extinction is a critical step toward development of new strategies in the treatment of human fear disorders. Here we used inhibitory component of AP-1 transcription factor, JunB, in order to map brain regions where JunB-dependent transcription is regulated during consolidation and extinction of contextual fear memory. We found that contextual fear memory consolidation induced JunB expression in the medial nucleus and intercalated cells of the amygdala while extinction training induced JunB in the CA1 and CA3 areas of the dorsal hippocampus. JunB upregulation induced by contextual fear memory extinction was absent in alphaCaMKII autophosphorylation-deficient mice which have impaired contextual fear memory extinction. Thus, our data suggest that JunB expression in the medial nucleus and intercalated cells of the amygdala is involved in fear memory consolidation while alphaCaMKII-autophosphorylation-dependent JunB expression in the areas CA1 and CA3 of the dorsal hippocampus regulates fear memory extinction.