دانلود مقاله ISI انگلیسی شماره161904
ترجمه فارسی عنوان مقاله

عوامل پیش آگهی معکوس برای بیماری های مریضی و مرگ و میر در طول سلول های بنیادی خون محیطی در بیماران مبتلا به آمیلوئیدوز زنجیره ای

عنوان انگلیسی
Adverse Prognostic Factors for Morbidity and Mortality During Peripheral Blood Stem Cell Mobilization in Patients with Light Chain Amyloidosis
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی ترجمه فارسی
161904 2018 23 صفحه PDF سفارش دهید
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منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Biology of Blood and Marrow Transplantation, Volume 24, Issue 4, April 2018, Pages 815-819

ترجمه کلمات کلیدی
آمیلوئیدوز، بسیج بنیادی هماتوپوئیدی، پیوند سلول بنیادی هماتوپوئیت، اثرات جانبی،
کلمات کلیدی انگلیسی
Amyloidosis; Hematopoietic stem cell mobilization; Hematopoietic stem cell transplantation; Adverse effects;
پیش نمایش مقاله
پیش نمایش مقالهعوامل پیش آگهی معکوس برای بیماری های مریضی و مرگ و میر در طول سلول های بنیادی خون محیطی در بیماران مبتلا به آمیلوئیدوز زنجیره ای

چکیده انگلیسی

Patients with immunoglobulin light chain (AL) amyloidosis undergoing peripheral blood hematopoietic stem cell (PBSC) mobilization for autologous hematopoietic stem cell transplantation (auto-HCT) can experience significant morbidity and mortality. The purpose of this study was to characterize the adverse events and identify prognostic factors associated with the development of morbidity and mortality in patients with AL amyloidosis who had begun PBSC mobilization for auto-HCT. A retrospective study was performed in 101 consecutive patients with AL amyloidosis who underwent PBSC mobilization for auto-HCT between January 2006 and December 2013. A composite primary endpoint of morbidity and mortality during PBSC mobilization was used. Forty-one patients (41%) experienced at least 1 adverse event, including 4 deaths during PBSC mobilization. Adverse events included in this composite endpoint were cardiac events, thromboembolic events, bleeding events, unplanned hospitalization, weight gain >2% necessitating diuretic intervention, and death. Low serum albumin levels, elevated N-terminal pro-brain natriuretic peptide, and increased interventricular septal thickness were significantly associated with the composite primary endpoint (P = .024, .001, and .006, respectively). The median progression-free survival from the start of PBSC mobilization was 4.7 years, and the median overall survival was 6.5 years. In general, PBSC mobilization is associated with minimal complications, but patients with AL amyloidosis can experience more frequent and severe complications, such as volume overload and weight gain. Careful patient selection is warranted in patients with AL amyloidosis before proceeding to PBSC mobilization and auto-HCT.

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