فعالیت و اتصالات کورتکس اوربیتوفرنتال پیش بینی علائم افسردگی آینده در نوجوانی

This study provides the first evidence for loss-related alterations in OFC functioning and its interaction with familial history of depression as possible mechanisms in the development of depression. While the current functional magnetic resonance imaging literature has mainly focused on reward, the current findings underscore the need to include prefrontal loss processing in existing developmental models of depression.