دانلود مقاله ISI انگلیسی شماره 128712
ترجمه فارسی عنوان مقاله

پردازش سیگنال درون کورتی از حساسیت لگن پریودنتال در موش صحرایی

عنوان انگلیسی
Intracortical signal processing of periodontal ligament sensations in rat
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی
128712 2017 13 صفحه PDF
منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : Neuroscience, Volume 355, 4 July 2017, Pages 212-224

پیش نمایش مقاله
پیش نمایش مقاله  پردازش سیگنال درون کورتی از حساسیت لگن پریودنتال در موش صحرایی

چکیده انگلیسی

The somatosensory information from the orofacial region, including the periodontal ligament (PDL), is processed in a manner that differs from that used for other body somatosensory information in the related cortices. It was reported that electrical stimulation to rat PDL elicited activation of the insular oral region (IOR) and the primary (S1) and secondary (S2) somatosensory cortices. However, the physiological relationship between S1 and S2/IOR is not well understood. To address this issue, we performed in vivo optical imaging using a voltage-sensitive dye. Our results demonstrated that the electrical stimulation to the PDL of the mandibular incisor evoked the simultaneous activation of S1 and the S2/IOR. The stimulation to the initial response area of the S1 evoked responses in the S2/IOR, and vice versa. An injection of tetrodotoxin (TTX) to the cortical region between S1 and S2/IOR attenuated such elicited responses only in the non-stimulated cortical partner site. The cortico-cortical interaction between S1 and S2/IOR was suppressed by the application of TTX, indicating that these two cortical regions bi-directionally communicate the signal processing of PDL sensations. An injection of FluoroGold™ (FG) to the initial response area in S1 or the S2/IOR showed that FG-positive cells were scattered in the non-injected cortical counterpart. This morphological result demonstrated the presence of a bi-directional intracortical connection between the initial response areas in S1 and the S2/IOR. These findings suggest the presence of a mutual connection between S1 and the S2/IOR as an intracortical signal processing network for orofacial nociception.