استعداد ژنتیکی به پیشرفت زیستی پیری باعث افزایش خطر ابتلا به اختلال افسردگی شدید در دوران کودکی در یک نمونه بزرگ انگلستان می شود

Genetic predisposition to advanced biological ageing, as assayed using rs10936599, predicted a small, but significant, increased risk for childhood-onset recurrent MDD. Genetic predisposition to advanced biological ageing may be one factor driving previously reported associations (or lack of associations) between shorter TL and MDD. Our results also suggest that the telomerase enzyme may act as a potentially important drug target for the prevention of childhood-onset MDD, at least in a subset of cases. Future studies should attempt to replicate our findings in a larger cohort.