بهبود زودرس و واکنش به داروهای ضد افسردگی در بزرگسالان مبتلا به اختلال افسردگی شدید. متاآنالیز و مطالعه نمونه ای با افسردگی مقاوم به درمان

Although literature data suggest a correlation between an initial improvement of depressive symptoms and later response and remission during AD treatment, our analysis shows that such an early improvement is not a reliable outcome predictor in TRD. The nature of TRD is complex and different biological mechanisms and treatments might be necessary for TRD patients.