دانلود مقاله ISI انگلیسی شماره 58519
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ضایعات نوزاد در ناحیه آمیگدال یا هیپوکامپ شکمی باعث مهار پاسخ مهیج صوتی می شود. پیامدهای یک مدل حیوانی از اختلالات رشد عصبی مانند اسکیزوفرنیا

عنوان انگلیسی
Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia
کد مقاله سال انتشار تعداد صفحات مقاله انگلیسی ترجمه فارسی
58519 2003 11 صفحه PDF سفارش دهید
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منبع

Publisher : Elsevier - Science Direct (الزویر - ساینس دایرکت)

Journal : European Neuropsychopharmacology, Volume 13, Issue 3, May 2003, Pages 187–197

ترجمه کلمات کلیدی
آمیگدالا، هیپوکامپ، مهار پیشگیری، وحشت زده شدن، مدل حیوانی، جنون جوانی
کلمات کلیدی انگلیسی
Amygdala; Hippocampus; Prepulse inhibition; Startle; Animal model; Schizophrenia

چکیده انگلیسی

Prepulse inhibition of the acoustic startle response is a behavioural tool applied to assess sensorimotor gating processes in humans and rats. Schizophrenic patients show deficits in prepulse inhibition of the acoustic startle response. The animal model of neurodevelopmental disorders such as schizophrenia, as purported in earlier reports and the present study, is based on the assumption that damage to brain structures early in life (on day 7) disrupts brain maturation of structures connected to the damaged areas, measurable by behavioural changes, whereas similar damage later in life (on day 21) does not result in these behavioural changes. Locomotor activity, the acoustic startle response and its prepulse inhibition were investigated in adult rats lesioned in the amygdala or ventral hippocampus on day 7 or 21 of life. The acoustic startle response was increased in animals lesioned in the amygdala on day 7 or 21 of life, but not in animals lesioned in the ventral hippocampus. Prepulse inhibition was impaired and locomotor activity enhanced in animals lesioned in the amygdala or ventral hippocampus on day 7, but not in animals lesioned in these structures on day 21 of life. The results on the acoustic startle response are suggestive of amygdaloid influences on modulation of the acoustic startle response. The effects of early postnatal lesions on prepulse inhibition and locomotor activity are in support of the animal model of neurodevelopmental disorders like schizophrenia.

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